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Sunday, October 8th, 2006 4:00pm - 6:00pm Registration Monday, October 9th, 2006 Pre-Symposium Special Topics Session 7:00am - 5:00pm Registration 7:00am - 8:15am Breakfast 8:15am - 8:30am   Welcome Address Speaker: Richard B. Belzer, PhD President Regulatory Checkbook Managing Editor NeutralSource.Org 8:30am - 9:15am  The role of depurinating DNA adducts in the initiation of cancer by aromatic hydrocarbons Speaker: Ercole Cavalieri, DSc Director University of Nebraska Center for Environmental Toxicology Professor Eppley Cancer Institute University of Nebraska Medical Center 9:15am - 10:00am  The role of depurinating DNA adducts in the initiation of cancer by estrogens Speaker: Eleanor Rogan, PhD Professor, the Eppley Institute Department of Biochemistry and Molecular Biology Department of Pharmaceutical Sciences University of Nebraska Medical Center 10:00am - 10:30am Break 10:30am - 11:15am  The role of error-prone base excision repair in generating mutations from aromatic hydrocarbon- and estrogen-induced DNA damage Speaker: Dhrubajyoti Chakravarti, PhD Research Assistant Professor Eppley Cancer Institute University of Nebraska Medical Center 11:15am - 12:00pm  'DNA DamageResponse to Naphthalene Metabolites' Speaker: Jun Nakamura, PhD Research Assistant Professor Environmental Sciences & Engineering School of Public Health UNC Chapel Hill 12:15pm - 1:45pm Lunch 2:00pm - 3:30pm  An Interactive Primer on Uncertainty Analysis for Exposure and Hazard Assessment Speaker: Mitchell J. Small, PhD The H. John Heinz III Professor of Environmental Engineering Professor, Deptarment of Engineering & Public Policy Carnegie Mellon University 3:30 pm Recess for the Day Tuesday, October 10th, 2006 Quintessential Science Issues in Naphthalene Risk Assessment 7:00am - 5:00pm Registration 7:00am - 8:15am Breakfast 8:15am - 8:30am  Weclome: Opening Remarks and Module A Speaker: D. Warner North, PhD President and Principal Scientist NorthWorks, Inc. Consulting Professor Department of Management Science and Engineering Stanford University 8:30am - 10:00am   Module A: Naphthalene Animal Bioassays Research Speakers: Kamal M. Abdo PhD Toxicologist (retired) NIEHS "NTP Carcinogenicity Studies of Naphthalene" Expert Panelists: Janet M. Benson, PhD, DABT Clinical Professor College of Pharmacy University of New Mexico Alan R. Dahl, PhD Senior Research Sceintist College of Medicine and Public Health Comprehensive Cancer Center The Ohio State University John Morris, PhD Director, Center for Biochemical Toxicology Head, Department of Pharmaceutical Sciences School of Pharmacy University of Connecticut Roger Renne DVM, DACVP Battelle Pacific Northwest Laboratories Hanspeter Witschi, MD Emeritus Professor Department of Molecular Biosciences School of Veterinary Medicine University of California, Davis 10:05am - 10:30am Break 10:30am - 12:00pm Module B: Exposure, Epidemiology and Human Cancer Incidence Commissioned Speaker: Paul Price MS President, The Lifeline Group "Available Data on Naphthalene Exposures: Strengths and Limitations" Expert Panelists: Kenneth Bogen, DrPh Environmental Health Scientist Lawrence Livermore National Laboratory Paul Price MS President, The Lifeline Group Douglas L. Weed MD, PhD Chief, Office of Preventive Oncology Dean of Education and Training Division of Cancer Prevention National Cancer Institute 12:00pm - 1:00pm Lunch 1:00pm - 5:30pm Module C: Anatomy, Physiology, and Metabolic Activation and Deactivation (Part I) 1:00pm - 3:00pm Research Speaker: Charles Plopper DVM Professor Department of Anatomy, Phsyiology & Cell Biology School of Veterinary Medicine University of California, Davis "Comparative pathobiology of naphthalene toxicity in the respiratory system: Pattern in adult mammals." 3:00pm-3:30pm Break 3:30pm-5:30pm Research Speakers: Laura S. Van Winkle, PhD Associate Research Cell Biologist Associate Adjunct Professor Department of Anatomy, Physiology & Cell Biology School of Veterinary Medicine University of California, Davis "Sex differences in Naphthalene toxicity" Michelle Fanucchi, PhD Assistant Research Cell Biologist Department of Anatomy, Physiology & Cell Biology School of Veterinary Medicine University of California, Davis "Postnatal Issues in Naphthalene Toxicity" Expert Panelists: Janet M. Benson, PhD, DABT Clinical Professor College of Pharmacy University of New Mexico Kenneth Bogen, DrPh Environmental health Sceintist Lawrence Livermore National Laboratory Harvey J. Clewell III, MA Director Center for Human Health Assessment Senior Scientist Division of Computational Biology CIIT Centers for Health Research Alan R. Dahl, PhD Senior Research Scientist College of Medicine and Public Health Comprehensive Cancer Center The Ohio State University Kannan Krishnan, PhD Professor Department of Environmental & Occupational Health University of Montreal John Morris, PhD Director, Center for Biomedical Toxicology Head, Department of Pharmaceutical Sciences School of Pharmacy, University of Connecticut Curt Omiecinski, PhD Professor of Veterinary Science H. Thomas and Dorothy Willits Hallowell Chair Department of Veterinary & Biomedical Sciences Penn State University Garold S. Yost, PhD Professor Department of Pharmacology & Toxicology Health Sciences Center University of Utah 5:30pm Recess for the Day 6:00pm - 8:00pm Reception Wednesday, October 11th, 2006 Quintessential Science Issues in Naphthalene Risk Assessment 7:00am - 5:00pm Registration 7:00am - 8:15am Breakfast 8:15am - 12:00pm Module C. Anatomy, Physiology, and Metabolic Activation and Deactivation (Part II) 8:15am - 10:15am Research Speaker: Alan Buckpitt, PhD Professor Department of Molecular Biosciences School of Veterinary Medicine University of California, Davis "Species comparisons in naphthalene metabolism and toxicity: what do data from recombinant proteins to whole animals tell us about human susceptibility?" 10:15am - 11:15am Break 11:15am-12:15pm Research Speaker: Harvey J. Clewell III, MA Director Center for Human Health Assessment Senior Scientist Division of Computational Biology CIIT Centers for Health Research "Physiologically based pharmacokinetic (PBPK) modeling of the respiratory tract effects of chemicals: considerations for developing a PBPK description for naphthalene" Expert Panelists: See Module C (Part 1) 12:15pm - 1:15pm Lunch Module D: Genotoxic Modes of Action 1:30pm - 2:30pm Commissioned Speaker: David Brusick, PhD, FATS "An Assessment of the Naphthalene Genetic Toxicology Database" 2:30pm - 3:00pm Break 3:30pm-5:00pm Research Speaker: Ercole L. Cavalieri, DSc Director University of Nebraska Center for Environmental Toxicology Professor, Eppley Cancer Institute University of Nebraska Medical Center "From aromatic hydrocarbons to estrogens and then back to benzene and naphthalene" Expert Panelists: David Brusick, PhD, FATS Xinxin Ding, PhD Research Scientist Human Toxicology and Molecular Epidemiology, Wadsworth Center NYS Department of Health Professor, Department of Biomedical Sciences & Environmental Health Sciences School of Public Health, SUNY Albany David Longfellow, PhD President Toxicology Forum Jun Nakamura, PhD Research Assistant Professor Environmental Sciences & Engineering School of Public Health UNC Capitol Hill Mitchell Small, PhD The H. John Heinz III Professor of Environmental Engineering Professor, Department of Engineering & Public Policy Carnegie Mellon University James Swenberg, PhD Professor Department of Environmental Sciences and Engineering UNC Chapel Hill 5:30pm Recess for the Day Thursday, October 12, 2006 Scientific Review and Uncertainty Analysis for Assessing Naphthalene Cancer Risk 7:00am - 12:00pm  Registration 7:00am - 8:00am  Breakfast 8:00am - 8:30am  Welcoming Address: Knowledge and Uncertainty, Captured Speaker: D. Warner North, PhD President and Chief Scientist Northworks, Inc. 8:30am - 9:15am  Presenters: Joshua Cohen, PhD Lecturer New England Medical Center "Applying to Naphthalene Lessons from the NAS Review of the Dioxin Reassessment" 9:15am-9:45am Break 9:45am - 10:45am  Module A: Naphthalene Animal Biossays Presenters: Facilitator & Panelists 10:45am - 11:45am Module B: Exposure, Epidemiology and Human Cancer Incidence 12:00pm - 1:00pm Lunch 1:00pm - 1:45pm  Module C: Anatomy, Physiology, and Metabolic Activation and Deactivation (Part 1) Presenters: Facilitator & Panelists 1:45pm - 2:30pm  Module C: Anatomy, Physiology, and Metabolic Activation and Deactivation (Part II) Presenters: Facilitator & Panelists 2:30pm - 3:00pm Break 3:00pm - 4:00pm   Module D: Genotoxic Modes of Action Presenters: Facilitator & Panelists 4:00pm - 4:30pm  Summary and Conclusion: Knowledge and Uncertainty, Containment and Management Speaker: D. Warner North, PhD President and Chief Scientist Northworks, Inc. 4:30pm Adjournment Website will be updated with additional details as available. Home | Program & Agenda | Invited Participants | Reference Material | Registration | Travel and Accomodations